Viral infections: The COVID-19 pandemic has spurred intense research into natural compounds that can boost the immune system, offering protection against SARS-CoV-2 and limiting the virus’s rapid transmission. One area of growing interest is the potential of bioactive compounds derived from mushrooms, which are not only easily sourced but also known for their high antioxidant activity, nutritional value, and minimal side effects.
Mushrooms in North-East India:
North-East India is home to diverse groups of edible mushrooms, contributing to the popularity of these fungi as a staple in the local diet. Researchers from the Institute of Advanced Study in Science and Technology (IASST), an autonomous institute under the Department of Science and Technology (DST), have taken a closer look at the significance of edible mushrooms and their bioactive molecules in attenuating complications associated with COVID-19 and other viral infections.
Research Analysis:
Led by Prof. Ashis K Mukherjee, the research group at IASST conducted a thorough analysis comparing current therapies against COVID-19 with the potential benefits of natural anti-infective, antiviral, anti-inflammatory, and antithrombotic products derived from mushrooms. Their study focused on 13 different mushroom-derived bioactive compounds, exploring their roles and mechanisms in preventing SARS-CoV-2 infection and mitigating associated pathophysiological effects.
Bioactive Compounds in Mushrooms:
The researchers highlighted the presence of bioactive polysaccharides and compounds in mushrooms that exhibit various medicinal properties, including immunomodulation, antiviral, antibacterial, and antifungal activities. Mushroom-based drugs are undergoing human trials, showing promising results against SARS-CoV-2.
Advantages of Edible Mushrooms:
One of the main advantages of using edible mushrooms against viral infections is their potential as a nutraceutical supplement with no discernible side effects. Mushrooms can act as potent immunity boosters, providing a natural and accessible means of enhancing the body’s defense mechanisms.
Opportunities for Further Research:
The study, published in the Journal of Fungi, suggests significant opportunities for advancing our understanding of mushroom-derived bioactive compounds through in-depth pre-clinical and clinical studies. The authors call for collaboration between researchers, health professionals, and policymakers to explore the full potential of these compounds in the fight against viral infections.
Conclusion:
As the world grapples with the ongoing challenges posed by viral infections, the humble mushroom emerges as a potential ally in the quest for effective and accessible treatments. The promising results from ongoing research underscore the need for continued exploration of mushroom-derived bioactive compounds, paving the way for innovative approaches to combating not only COVID-19 but also other viral threats. With a coordinated effort from the scientific community, healthcare professionals, and policymakers, the therapeutic potential of mushrooms may open new avenues in the global fight against infectious diseases.
Viral infections:
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